https://www.reddit.com/r/Qubes/comments/tnib7k/guide_on_using_a_usb_audio_device_with_qubes_41/
I have bumped on this on r/Qubes yesterday. I'm still trying to make it work. I'm stuck at last command, because I don't know the syntax of usb device name in it. That is why I didn't put it to Guides.
If someone is willing to try, it would be great to share findings.
Please keep in mind that sys-audio that is mentioned there most probably is not not sys-audio in terms of Qubes 4.1